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Fluconazole diflucan 150 mg tablet taken orally twice daily at night Brynden-Goldring et al. 2012 Brynden-Goldring et al. 2012 Study Design: Single blind, randomized, parallel, placebo controlled Setting: University medical center, St. Louis, MO Patients: One hundred and forty patients meeting DSM-IV (American Psychiatric Association) criteria for social anxiety disorder, defined by a maximum score of 35 Interventions: A total of 150 mg imipramine hydrochloride was administered orally twice daily for 14 days. A single dose of duloxetine hydrochloride 100 mg was administered to subjects for 13 days. A single dose of citalopram hydrochloride 100 mg was administered to subjects for 13 days. All patients were re-exposed 6 weeks later. Main Outcome Measures: Change of Hamilton Depression Scale (HAM-D; 0–24), Beck Inventory (BDI; Social Phobia Scale (SPS; 0–23), and the Montgomery–Asberg Depression Rating Scale (MADRS; 0–24) scores from baseline to week 14. Results: Imipramine had no significant effects on HAM-D or BDI scores BSDS scores. Citalopram was significantly more effective than imipramine at reducing depression (p <.0001) and social phobia (p <.0002). Conclusions: Imipramine was superior to citalopram at reducing depression and social phobia severity in patients meeting DSM-IV for social anxiety disorder.
